Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine resistance to antimalarail drugs Side affects of plaquenil Acute chloroquine toxicity Delayed side effects plaquenil Conclusion. Hydroxychloroquine and chloroquine has become a mainstay in the DMARD management of inflammatory disease. While very effective, the use of the medication carries the risk of retinotoxicity that is most directly tied to pre-existing retinal disease and cumulative dosage. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. After the surgery, the blind area was more noticeable because my sight in that eye was so much clearer,” she says. “The surgeon sent me to a retina specialist, who recommended that I cut down my dose of Plaquenil. Finally, my rheumatologist recommended that I stop taking the drug altogether.” Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Eye retinal toxicity dosage hydroxychloroquine HCQ Retinopathy Update 2019 - Acuity Eye Center, Hydroxychloroquine-Induced Retinal Toxicity - American Academy of. How to say plaquenilPlaquenil versus hydroxychloroquine It’s generally safe at normal doses, but higher amounts can damage the retina, the light-sensitive tissue at the back of the eye, and result in partial or complete blindness. Hydroxychloroquine-related eye problems were once considered rare, but better detection methods now show that they occur in about 7 percent of patients. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at.. Protecting your eyesight when taking Plaquenil Lupus.. New Plaquenil Guidelines. Our study showed that approximately 30% of the patients treated with HCQ had retinal toxicity. There was no association between retinal toxicity and sex, type of rheumatic disease, and daily HCQ dose. However, there was a positive correlation between retinal toxicity and age, cumulative HCQ dose, and duration of HCQ use. No retinal toxicity causing visual loss was found. On the basis of these results and a review of the recent literature we no longer routinely screen patients for hydroxychloroquine retinal. In some people, Plaquenil can cause a condition called hydroxychloroquine retinopathy, often referred to as bulls-eye maculopathy. The condition sometimes resembles a target, or bulls-eye ring, on the retina surrounding the macula.